Controlling escape from angiogenesis inhibitors
نویسندگان
چکیده
منابع مشابه
Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.
PURPOSE Thrombospondin-1 (Tsp1), endostatin, and tumstatin are extracellular matrix-associated proteins that inhibit angiogenesis. We examined the mechanisms by which tumor cells may bypass the antiangiogenic effects of these endogenous regulators. EXPERIMENTAL DESIGN CT26 colon and RenCa renal carcinoma cells were stably transfected with Tsp1, endostatin, or tumstatin cDNA. Subcutaneous and ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2012
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3366